Endocrine Abstracts

Prolactin (PRL) exists in different forms in human serum. The predominant form is little PRL (23 kDa) with smaller amounts of big PRL (50–60 kDa), that may be also associated with big big PRL (bbPRL) or macroprolactin (150–170 kDa). A lower biological activity in vivo of bbPRL was reported. Aim of the study was to evaluate the clinical impact of macroprolactin and the association between macroprolactinaemia and polycystic ovary syndrome (PCOS). A group of 115 ...

Introduction: Patients with adrenal incidentalomas (AI) and subclinical hypercortisolism (SH) are thought to have increased incidence of cardiovascular risk factors, including diabetes mellitus (DM) and hypertension. Data regarding dyslipidemia are scarce. The aim of this study is to evaluate the possible influence of SH on lipid pattern in relation to the presence/absence of DM.Methods and design: 276 AI patients were enrolled (168 F, 108 M), 55 with di...

Background: Impaired glucose (G) regulation (IGR) and diabetes mellitus (DM) are common in patients with liver cirrhosis. DM development has been associated to advanced liver disease (LD) and HCV infection. The relative roles played by insulin secretion and action, advanced LD and HCV infection in DM are somewhat unclear.Aim of the study: To assess in cirrhotic patients candidate to organ transplantation with no history of G abnormalities: i) prevalence ...

Background: Metabolic syndrome (MS) is a common condition among liver transplanted patients and it contributes to late morbidity and mortality by favoring the development of cardiovascular disease (CVD).The aim of this study was to assess the prevalence of MS in the first 6 months after orthotopic liver transplantation (OLT) and the associated pre-operative and post-operative risk factors.Methods: Seventy-one cirrhotic patients wer...

Introduction: Williams syndrome (WS) is a rare, multisystemic genomic disorder. While the natural history of the disease in childhood is quite well-known, few descriptions of the adult WS medical complications have been published.Method: Twenty-two young adult patients with WS (13 females, 9 males, age: 29.2±5.4 years) were studied. A 75 g oral glucose tolerance test (OGTT) was performed in all but one with known diabetes mellitus (DM). β-Cell ...